Original Research Articles

Unless otherwise noted

* Indicates Equal Contribution, Bolded Indicates Lab Members

2023

• Salama R, DiLoreto EM, Srinivasan J. “The Architect of Neurotransmission in C. elegans: How FLP-3 Neuropeptides Structures Direct their Function.” microPublication Biology. In review
• Reilly DK, Schwarz EM, Muirhead CS, Robidoux AN, Narayan A, Doma MK, Sternberg PW, & Srinivasan J. (2023). “Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans.” Genetics, 223(4), iyad026. doi.org/10.1093/genetics/iyad026

2022

• Walsh JD, Wang J, DeHart M, Nikonorova IA, Srinivasan J, Barr MM. (2022). “Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles.” PLoS Genet. 18(12):e1010560. doi: 10.1371/journal.pgen.1010560. PMID: 36574451; PMCID: PMC9829181.
• McLachlan IG, Kramer TS, Dua M, DiLoreto EM, Gomes MA, Dag U, Srinivasan J, Flavell SW. (2022) “Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior.” Elife. 11:e79557. doi: 10.7554/eLife.79557. PMID: 36044259; PMCID: PMC9433090.

2021

• Reilly DK, McGlame EJ, Vandewyer E, Robidoux AN, Northcott HT, Joyce W, Alkema MJ, Gegear RJ, Beets I, Srinivasan J. (2021). “Distinct Neuropeptide-Receptor Modules Regulate a Sex-Specific Behavioral Response to a Pheromone.” Communications Biology. 4: 1018. doi.org/10.1038/s42003-021-02547-7.

• DiLoreto EM, Reilly DK, Srinivasan J. (2021). “Non-Transgenic Functional Rescue of Neuropeptides”. bioRxiv. (In review)

2020

• Muirhead CS, Srinivasan J. (2020). “Small molecule signals mediate social behaviors in C. elegans.“ Journal of Neurogenetics. 34:3-4, 395-403. doi.org/10.1080/01677063.2020.1808634. (Review)

2019

• Reilly DK, Srinivasan J. (2019). Current Biology. doi.org/10.1016/j.cub.2019.10.031. “Chemical Communication: Linking Behavior and Physiology.” Current Biology. doi.org/10.1016/j.cub.2019.10.031. (Dispatch)
• Zhang YK*, Reilly DK*, Yu J, Srinivasan J, Schroeder FC. (2019). “Photoaffinity probes for nematode pheromone receptor identification.” Organic & Biomolecular Chemistry.  doi.org/10.1039/C9OB02099C.

• Pearce KM, Bell M, Linthicum WH, Wen Q, Srinivasan J, Rangamani P, Scarlata S. (2019). “Gq-mediated calcium dynamics and membrane tension modulate neurite plasticity.” Molecular Biology of the Cell.  doi.org/10.1091/mbc.E19-09-0536.

• Reilly DK*, Randle LJ*, Srinivasan J. (2019). “Evolution of hermaphroditism decreases efficacy of Ascaroside#8-mediated mate attraction in Caenorhabditis nematodes.”  microPublication. doi.org/10.17912/micropub.biology.000134.

• DiLoreto EM, Chute CD, Bryce S, Srinivasan J. (2019).  “Novel technological Advances in Functional Connectomics in C. elegans.” Journal of Developmental Biology. 7(2), 8. doi.org/10.3390/jdb7020008.(Review)
• Chute CD, DiLoreto EM, Zhang YK, Reilly DK, Rayes D, Coyle VK, Choi HJ, Alkema MJ, Schroeder FC, Srinivasan J. (2019). “Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans.” Nature Communications. doi.org/10.1038/s41467-019-11243-7.
  
• Liu Z*, Kariya MJ*, Chute CD*, Pribadi AK, Leinwand SG, Tong A, Curran KP, Bose N, Schroeder FC, Srinivasan J, Chalasani SH. (2019). “The Chemistry of Fear.” Natural History. 127(3):12-13. (Field Note)

• Lee JB, Yonar A, Hallacy T, Shen CH, Milloz J, Srinivasan J, Kocabas A, Ramanathan S. (2019).  “A compressed sensing framework for efficient dissection of neural circuits.” Nature Methods. 16(1):126-133. doi.org/10.1038/s41592-018-0233-6.

2018

• Liu Z*, Kariya MJ*, Chute CD*, Pribadi AK, Leinwand SG, Tong A, Curran KP, Bose N, Schroeder FC, Srinivasan J, Chalasani SH. (2018). “Predator-secreted sulfolipids induce defensive responses in C. elegans.” Nature Communications. 9(1):1128. doi.org/10.1038/s41467-018-03333-6.

• Dong C, Reilly DK, Bergame C, Dolke F, Srinivasan J, von Reuss SH. (2018). “Comparative Ascaroside Profiling of Caenorhabditis Exometabolomes Reveals Species-Specific (ω) and (ω–2)-Hydroxylation Downstream of Peroxisomal β-Oxidation.” The Journal of Organic Chemistry. doi.org/10.1021/acs.joc.8b00094

2017

• Reilly DK, Lawler DE, Albrecht DR, Srinivasan J. (2017). “Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. elegans Head Neurons.” Journal of Visualized Experiments. 127, (e56026). doi.org/10.3791/56026.

• Reilly DK, Srinivasan J. (2017). Caenorhabditis elegans Olfaction. Oxford Research Encyclopedia of Neuroscience. doi.org/10.1093/acrefore/9780190264086.013.191. (Book Chapter)
  

2016

• Narayan A, Venkatachalam V, Durak O, Reilly DK, Bose N, Schroeder FC, Samuel AD, Srinivasan J, Sternberg PW. (2016). “Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans.” Proc Natl Acad Sci U S A. 113(10):E1392-401. doi.org/10.1073/pnas.1600786113.

2015

• Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC. (2015). “POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.” Dev Cell. 34(1):108-18. doi.org/10.1016/j.devcel.2015.05.024.             

• Reilly DK, Srinivasan J. (2015). “Reproductive Evolution: Pulling the Plug on Selection.” Curr Biol. 25(20):R984-6. doi: 10.1016/j.cub.2015.09.008. (Review)

  

2014

• Chute CD, Srinivasan J. (2014). “Chemical Mating Clues in C. elegans.“ Seminars in Cell & Developmental Biology. 33:18-24. doi.org/10.1016/j.semcdb.2014.06.002. (Review)
• Srinivasan J, Rakowski F. (2014). “Synaptic Polarity of the Interneuron Circuit Controlling C. elegans Locomotion.” Frontiers in Computational Neuroscience. doi.org/10.3389/fncom.2013.00128

2013

•  Artyukhin AB, Yim JJ, Srinivasan J, Izrayelit Y, Bose N, von Reuss SH, Jo Y, Jordan JM, Baugh LR, Cheong M, Sternberg PW, Avery L, Schroeger FC. (2013). “Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans.” Biological Chemistry. 288(26), 18778-83.

2012

• *Srinivasan, J, *Dillman AR, Mortazavi A, Fracchia, KM, Heikkinen, L, Lakso, M, Antoshechkin I, Wong, G, Sternberg PW. (2012). “The draft genome and transcriptome of Panagrellus redivivus is shaped by the harsh demands of a free-living lifestyle.” Genetics. 193(4): 1279-1295.
  

• Izrayelit Y, Srinivasan J, Campbell SL, Jo Y, von Reuss SH, Genoff MC, Sternberg PW, Schroeder FC. (2012). “Targeted metabolomics reveals a male pheromone and sex-specific ascaroside biosynthesis in C. elegans.” ACS Chemical Biology. 7(8), 1321-25.
• Kroetz, SM, Srinivasan J, Yaghoobian J, Sternberg PW, Hong RL. (2012). “The cGMP Signaling and Food Quality Affect Feeding Behavior in the necromenic nematode Pristionchus pacificus.” PLoS One. 7(4), e34464.
  
• von Reuss, SH, Bose, N., Srinivasan, J, Yim, JJ, Judkins, JC, Sternberg, PW, Schroeder, FC. (2012).  “Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small molecule signals in C. elegans.” JACS. 134(3), 1817-1824.
• Srinivasan J*, von Reuss, SH*, Bose, N, Mahanti P, Ho, MC, O’Doherty OG, Edison, AE, Sternberg PW, Schroeder FC. (2012). “A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans.” PLoS Biology. 10(1), e1001237.
  **Highlighted in a review in PLoS Biology, “New Signaling Chemicals Spur Worms to Seek Company.” PLoS Biology. 10(1), e1001240.**

2011

• Chung K*, Zhan M*, Srinivasan J, Sternberg PW, Gong E, Schroeder FC, Lu H. (2011).  “Microfluidic chamber arrays for whole-organism high-throughput chemical screening.” Lab on a Chip. 11(21), 3689-97.
  
• Kaplan F, Srinivasan J,  Mahanti P, Ajredini R, Durak O, Nimalendran R, Sternberg PW, Teal PEA, Schroeder FC, Edison AS, Alborn HT.  (2011).”Ascaroside expression in Caenorhabditis elegans is strongly dependent on diet and developmental stage.” PLoS One. 6(3), e17804.
  

2010

• Rivard LM*, Srinivasan J*, Stone A, Ochoa S, Sternberg PW, Loer CM. (2010). “A comparison of experience-dependent locomotory behaviors and biogenic amine neurons in nematode relatives of Caenorhabditis elegans.” BMC Neuroscience. 11, 22.
  

2009

• Pungaliya C, Srinivasan J, Fox BW, Malik RU, Ludewig AH, Sternberg PW, Schroeder FC. (2009).”A shortcut to identifying small molecule signals regulating behavior and development in Caenorhabditis elegans.” PNAS. 106(19), 7708-13.
  **Highlighted in a review in PNAS, “DANSing with Caenorhabditis elegans.” PNAS (2009). 106, 7685-86.**

2008

• Srinivasan J, Durak O, Sternberg PW. (2008). “Evolution of a polymodal sensory response network.” BMC Biology. 6, 52.
  **Highlighted in a mini review in Journal of Biology, “Neuronal remodeling on the evolutionary timescale.” Journal of Biology. (2008). 7, 37.**
• Srinivasan J*, Kaplan F*, Ajredini R, Zachariah C, Alborn HT, Teal PEA, Malik RU, Edison AS, Sternberg PW, Schroeder FC. (2008). “A blend of small molecules regulates both mating and development in Caenorhabditis elegans.” Nature. 454, 1115-1118.
  **Highlighted in Nature Chemical Biology, “To mate or to dauer.” Nature Chemical Biology. (2008). 4, 533.**
  

• Srinivasan J, Sternberg PW. (2008). “Pristionchus pacificus: an appropriate fondness for Beetles.” Nature Genetics. 40(10), 1146-1147. (Review)

  

2007

• Ratsch G, Sonnenburg S*, Srinivasan J*, Witte H, Muller KR, Sommer RJ, Scholkopf B. (2007). “Improving the Caenorhabditis elegans genome annotation using machine learning.” PLoS Comput Biol. 3(2), e20.
  

2006

• Dieterich C, Roeseler W, Srinivasan J. (2006). “Pristionchus pacificus genomics: From genetics to genome sequence.” Wormbook. doi.org/10.1895/wormbook.1.116.1. (Book Chapter)
  

2004

• Srinivasan J, Otto GW, Kahlow U, Geisler R, Sommer RJ. (2004). “AppaDB: An AcedB- database for the nematode satellite organism Pristionchus pacificus.” Nuc. Acids Res. 32, D421-422.

2003

• Srinivasan J, Sinz W, Jesse T, Wiggers-Perebolte L, Jansen K, Buntjer J, van der Meulen M, Sommer RJ. (2003). “An integrated physical and genetic map of the nematode Pristionchus pacificus.“ Mol. Gen. Genomics. 269, 715-722.
  
• Srinivasan J, Sommer RJ. (2003). “The C. elegans genome: Comparative sequencing.” Encyclopedic Reference of Genomics and Proteomics. (Book Chapter)

2002

• Srinivasan J, Sinz W, Lanz C, Brand A, Nandakumar R, Raddatz G, Witte H, Keller H, Kipping I, Silva da Pires A, Jesse T, Millare J, DeBoth M, Schuster SC, Sommer RJ. (2002). “A Bacterial Artificial Chromosome-Based Genetic Linkage Map of the Nematode Pristionchus pacificus.” Genetics. 162, 129-134.
  
• Srinivasan J, Sommer RJ. (2002). “From evolutionary developmental biology to genomics: towards a genome map of the free living nematode Pristionchus pacificus.”  International Congress Series. 1246, 101-110. (Review)
  

2001

• Srinivasan J*, Silva da A*, Gutierrez A*, Zheng M, Jungblut B, Witte H, Schlak I, Sommer RJ. (2001). “Microevolutionary analysis of the nematode genus Pristionchus suggests a recent evolution of redundant developmental mechanisms during vulva formation.”  Evolution and Development. 3(4), 1-12.

2000

• Sommer RJ, Carmi I, Eizinger A, Grandien K, Jungblut B, Lee KZ, Nguygen H, da Silva AP, Schlak I, Sigrist C, Srinivasan J. (2000). “Pristionchus pacificus: A satellite organism in evolutionary developmental biology.” Nematology. 2(1), 81-88. 

1999

• Scheel J, Srinivasan J, Honnert U, Henske A, Kurzchalia T. (1999). “Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans.”  Nature Cell Biol. 1(2), 127-9.
  **Highlighted in a commentary in Nature Cell Biology. “Caveolin, cholesterol and Ras signalling.” Nature Cell Biology. (1999). 1, E35-E37.**