For the most up to date information please via my profiles on My NCBI and Google Scholar.

List of Peer-Reviewed Journal Articles

Asterisks (*) indicate publications of work performed at WPI with WPI undergraduate students in italics, graduate students underlined. # indicates co-first authors. § indicates corresponding author.

  1. *,§ Villarreal-Otalvaro C, Coburn JM. (2021) Fabrication methods and form factors of gellan gum-based materials for drug delivery and anti-cancer applications. Accepted ACS Biomaterials Science and Engineering. DOI: 10.1021/acsbiomaterials.1c00685
  2. Bond KH, Chiba T, Wynne KPH, Vary CPH, Sims-Lucas S, Coburn JM, Oxburgh L. (2021) The extracellular matrix environment of clear cell renal cell carcinoma determines cancer associated fibroblast growth. Cancers, 13, 5873.
  3. *,§ Abbott A, Coburn JM. (2021) HepaRG maturation on silk fibroin scaffolds toward development of a 3D in vitro liver model, Accepted ACS Biomaterials Science and Engineering. DOI: 10.1021/acsbiomaterials.0c01584
  4. Keutgen XM, Ornell KJ, Vogl A, Lakiza O, Miller P, Beckett M, Setia N, Weichselbaum RR, Coburn JM. (2021) Sunitinib-loaded chondroitin sulfate hydrogels as a novel drug-delivery system for the treatment of pancreatic neuroendocrine tumors, Annals of Surgical Oncology. DOI: 10.1245/s10434-021-10245-1
  5. *,§ Abbott A, Bond K, Chiba T, Sims-Lucas S, Oxburgh L, Coburn JM. (2021) Development of a mechanically matched silk scaffolded 3D clear cell renal cell carcinoma model, Materials Science and Engineering: C. 126:11214.
  6. *,§ Ornell KJMistretta KSRalston CQ, Coburn JM. (2021) Development of a stacked, porous silk scaffold neuroblastoma model for investigating spatial differences in cell and drug responsiveness. Biomaterials Science. 9:1272-1290.
  7. *,§ Ornell KJ, Chiu, B, Coburn JM. (2021) Development of a dinutuximab delivery system using silk foams for GD2 targeted neuroblastoma cell death. Journal of Biomedical Research Part A. 109(8):1393-1405.
  8. *,§ Ornell KJ, Mistretta KS, Ralston CQ, Coburn JM. (2020) Development of a stacked, porous silk scaffold neuroblastoma model for investigating spatial differences in cell and drug responsiveness. Biomaterials Science. DOI: 10.1039/D0BM01153C.
  9. * Carnes ME, Gonyea CR, Mooney RG, Njihia JW, Coburn JM, Pins GD. (2020) Horseradish peroxidase-catalyzed crosslinking of fibrin microthread scaffolds. Tissue Engineer Part C. 26(6):317-331.
  10. *,§ Montoya NV, Peterson R, Ornell KJ, Albrecht DR, Coburn JM. (2020) Silk particle production based on silk/PVA phase separation using a microfabricated co-flow device. MDPI Molecules. 25(4): 890.
  11. *,§ Ornell KJ, Taylor JS, Zeki J, Ikegaki N, Shimada H, Coburn JM, Chiu B. (2020) Local delivery of Dinutuximab from silk protein biomaterial for treatment of orthotopic neuroblastoma model. Cancer Medicine. DOI: 10.1002/cam4.2936.
  12. *,§ Phan NV, Wright T, Xu J, Coburn JM. (2020) In vitro biocompatibility of decellularized cultured plant cell-derived matrices. ACS Biomaterials Science and Engineering. 6(2): 822-832.
  13. Taylor JS, Yavuz B, Zeki J, Wood L, Ikegaki N, Coburn J, Harrington K, Shimada H, Kaplan DL, Chiu B. (2020) Enhancing sustained-release local therapy: Single versus dual chemotherapy for the treatment of neuroblastoma. Surgery. 167(6):969-977.
  14. *,§ Ornell KJ, Mistretta KS, Newman E, Ralston CQ, Coburn JM. (2019) Three-dimensional, scaffolded tumor model to study cell-driven microenvironment effects and therapeutic responses. ACS Biomaterials Science and Engineering. 5(12): 6742-6754.
  15. * Taylor JS, Zeki J, Ornell K, Coburn J, Shimada H, Ikegaki N, Chiu B. (2019) Down-regulation of MYCN protein by CX-5461 leads to neuroblastoma tumor growth suppression. Journal of Pediatric Surgery. 54(6):1192-1197.
  16. Taylor JS, Sha L, Ikegaki N, Zeki J, Deaton R, Harris J, Coburn J, Sethi A, Shimada H, Kaplan DL, Gann P, Chiu B. (2019) Replicating and identifying large cell neuroblastoma using high-dose intra-tumoral chemotherapy and automated digital analysis. Journal of Pediatric Surgery. 54(12): 2595-2599.
  17. Yavuz B, Zeki J, Harrington K, Coburn J, Ikegaki N, Kaplan D, Chiu B. (2019) Silk reservoirs for local delivery of cisplatin for neuroblastoma treatment: In vitro and in vivo evaluation. Journal of Pharmaceutical Sciences. 108(8):2748-2755.
  18. Gupta AK, Sarkar P, Coburn JM, Davis-Knowlton J, Palma EK, Kaplan DL, Oxburgh L. (2019) Scaffolding kidney organoids on silk. Journal of Tissue Engineering and Regenerative.
  19. * Ornell KJ, Phan NV, Lozada D, Coburn JM. (2019) Controlling methacryloyl substitution of chondroitin sulfate: Injectable hydrogels with tunable long-term drug release profiles. Journal of Materials Chemistry B.
  20. *,§ Ornell KJ, Coburn JM. (2019) Developing preclinical models of neuroblastoma: driving therapeutic testing. BMC Biomedical Engineering, 1:33.
  21. *van ZyL E, Coburn JM. (2019) Hierarchical structure of bacterial-derived cellulose and impact on biomedical applications. Current Opinion in Chemical Engineering, 24:122-130.
  22. Zeki J, Taylor JS, Yavuz B, Coburn J, Ikegaki N, Kaplan DL, Chiu B. (2018) Disseminated injection of vincristine-loaded silk gel improves the suppression of neuroblastoma tumor growth. Surgery. 164(4):909-915.
  23. *Abbott AA, Oxburgh L, Kaplan DL, Coburn JM. (2018) Electrostatic immobilization of avidin onto silk surfaces to non-covalently conjugate cell signaling molecules. Biomacromolecules. 19(9):3705-3713.
  24. Yavuz B, Zeki J, Coburn JM, Ikegaki N, Levitin D, Kaplan DL, Chiu B. (2018) In vitro and in vivo evaluation of etoposide-silk wafers for neuroblastoma treatment. Journal of Controlled Release. 3:162-171.
  25. Zeki J, Taylor JS, Yavuz B, Coburn J, Ikegaki N, Kaplan D, Chiu B. (2018) Disseminated injection of vincristine-loaded silk gel improves the suppression of neuroblastoma tumor growth. Surgery. pii: S0039-6060(18)30330-1.
  26. Ashari N, Pang HW, Simon T, Xiong Y, Coburn JM, Bromberg JS, Kaplan DL, McLenithan J, Fontaine MJ. (2018). Silk fibroin preserves beta cell function under inflammatory stress while stimulating islet cell surface GLUT2 expression. Cell Immunology. 329:10-16.
  27. Montalbán MG, Coburn JM, Lozano-Pérez AA, Cénis JL, Víllora G, Kaplan DL. (2018) Curcumin-Loaded Silk Fibroin Nanoparticles for Cancer Therapy. 8(2):126.
  28. *Niemas-Teshiba R, Matsuno R, Wang L, Tang X, Chiu B, Zeki J, Coburn J, Ornell K, Naranjo A, Van Ryn C, London W, Hogart M, Gastier-Foster J, Look AT, ParK J, Maris J, Cohn S, Seeger R, Asgharzadeh S, Ikegaki N, Shimada H. (2017) MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive High-MKI Neuroblastomas: A Report from the Children’s Oncology Group. Oncotarget. 9(5):6416-6432.
  29. McGill M, Coburn JM, Partlow BP, Mu X, Kaplan DL. (2017) Molecular and macro-scale analysis of enzyme-crosslinked silk hydrogels for rational biomatieral design. Acta Biomaterialia. pii: S1742-7061(17)30583-4.
  30. Coburn JM, Harris J, Cunningham R, Zeki J, Kaplan DL, Chiu B. (2017) Manipulation of variables in local controlled release vincristine treatment in neuroblastoma. Journal of Pediatric Surgery.  pii: S0022-3468(17)30525-0.
  31. Zhang L, Herrera C, Coburn J, Olejniczak N, Ziprin P, Kaplan DL, LiWang PJ. (2017) Stabilization and sustained release of HIV inhibitors by encapsulation in silk fibroin films. ACS Biomaterials Science and Engineering. 3(8):1654-1665.
  32. Pellis A, Silvestrini L, Scaini D, Coburn JM, Gardossi L, Kaplan DL, Acero EH, Guebitz GM. (2017) Enzyme-catalyzed functionalization of poly(L-lactic acid) for drug delivery applications. Process Biochemistry. 59: 77-83.
  33. Brown JE, Moreau JE, Berman AM, McSherry HJ, Coburn JM, Schmidt DF, Kaplan DL. (2017) Shape memory silk protein sponges for minimally invasive tissue regeneration. Advanced Healthcare Materials. 6(2).
  34. Coburn JM#, Harris J#, Zakharov AD, Poirier J, Ikegaki N, Kajdacsy-Balla A, Pilichowska M, Lyubimov AV, Shimada H, Kaplan DL, Chiu B. (2017) Implantation of Chemotherapy-Loaded Controlled Release Platform within Neuroblastoma Tumor. International Journal of Cancer. 140(3):726-735.
  35. Brown JE, Moreau JE, Berman AM, McSherry HJ, Coburn JM, Schmidt DF, Kaplan DL. (2017) Shape memory silk protein sponges for minimally invasive tissue regeneration. Advanced Healthcare Materials. 6(2).
  36. Kumar M, Coburn JM, Kaplan DL, Mandal BB. (2016) Immuno-informed 3D sil-biomaterials for tailoring biological responses. Applied Materials and Interfaces. 8(43):29310-29322.
  37. Harris JC, Coburn JM, Kajdacsy-Balla A, Kaplan DL, Chiu B. (2016) Sustained delivery of vincristine inside an orthotopic mouse sarcoma model decreases tumor growth. Journal of Pediatric Surgery, S0022-3468(16): 30363-3.
  38. Sundarakrishnan A, Acero EH, Coburn J, Chwalek K, Partlow B, Kaplan DL. (2016) Phenol red-silk tyrosine cross-linked hydrogels. Acta Biomaterialia, 42:102-13.
  39. Zhao S, Chen Y, Partlow BP, Golding AS, Tseng P, Coburn J, Applegate MB, Moreau JE, Omenetto FG, Kaplan DL. (2016) Bio-functionalized silk hydrogel microfluidic systems. Biomaterials, 93:60-70.
  40. Kim C, Jeon OH, Kim DU, Chae J, Shores L, Bernstein N, Bhattacharya R, Coburn JM, Yarema KJ, Elisseeff JH. (2016) Local delivery of a carbohydrate analog for reducing arthritic inflammation and rebuilding cartilage. Biomaterials, 83:93-101.
  41. Applegate MB, Partlow BP, Coburn J, Marelli B, Pirie C, Pineda R, Kaplan DL, Omenetto FG. (2016) Photocrosslinking of silk fibroin using riboflavin for ocular prostheses. Advanced Materials, 28(12):2417-20.
  42. Coburn JM, Na E, Kaplan DL. (2015) Modulation of Vincristine and Doxorubicin Binding and Release from Silk Films. Journal of Controlled Release, 220 (Pt A): 229-238.
  43. Applegate MB, Coburn J, Partlow BP, Moreau JE, Mondia JP, Marelli B, Kaplan DL, Omenetto FG. (2015) Laser-based three-dimensional multiscale micropatterning of biocompatible hydrogels for customized tissue engineering scaffolds. Proceedings of the National Academy of Science USA, 112(39):12052-12057.
  44. Seib FP, Coburn J, Konrad I, Klebanov N, Jones GT, Blackwood B, Charest A, Kaplan DL, Chiu B. (2015) Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo. Acta Biomaterialia, 20:32-38.
  45. Coburn JM, Kaplan DL. (2015) Engineering material-drug conjugates for sustained chemotherapeutic delivery. Bioconjugate Chemistry, 26(7):1212-1223.
  46. Brown J, Lu C, Coburn J, Kaplan DL. (2015) Impact of silk biomaterial structure on proteolysis. Acta Biomaterialia. 11:212-221.
  47. Franck D, Chung YG, Coburn J, Kaplan D, Estrada C, Mauney J. (2014) In vitro evaluation of bi-layer silk fibroin scaffolds for gastrointestinal tissue engineering. Journal of Tissue Engineering, 5:2041731414556849.
  48. Bhattacharjee M#, Coburn J#, Centola M#, Murab S, Barbero A, Kaplan DL, Martin I, Ghosh S. (2014) Tissue engineering strategies to study cartilage development, degeneration and regeneration. Advanced Drug Delivery Reviews. 84:107-122.
  49. Chiu B, Coburn J, Pilichowska M, Holcroft C, Seib P, Charest A, Kaplan DL. (2014) Surgery combined with controlled-release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model. British Journal of Cancer. 11(4):708-15.
  50. Gibson M, Beachley V, Coburn J, Alain-Bandinelli P, Mao HQ, Elisseeff J. (2014) Tissue extracellular matrix nanoparticle presentation in electrospun nanofibers. BioMed Research International. Article ID 469120.
  51. Gibson M, Li H, Coburn J, Moroni L, Nahas Z, Bingham C, Yarema K, Elisseeff J.(2014) Intra-articular delivery of glucosamine for treatment of experimental osteoarthritis created by a medial meniscectomy in a rat model. Journal of Orthopaedic Research. 32(2):302-309.
  52. Coburn JM, Wo L, Bernstein N, Bingham CO, Yarema KJ, Elisseeff JH. (2013) Short-chain fatty acid-modified hexosamine for tissue-engineering osteoarthritic cartilage. Tissue Engineering. 19(17-18):2035-44.
  53. Coburn JM, Yarema KJ, Elisseeff JH. (2013) Differential response of chondrocytes and chondrogenic mesenchymal stem cells to C1-OH tributanoylated hexosamines. PLOS ONE. 8(3):e58899.
  54. Sharma BS, Gibson M, Unterman S, Herzka DA, Cascio B, Coburn J, Hui AY, Marcus N, Gold GE, Elisseeff JH. (2013) Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite. Science Translation Medicine. 5(167):167ra6.
  55. Coburn JM, Gibson M, Monagle S, Patterson Z, Elisseeff JH. (2012) Bioinspired nanofibers mediate articular cartilage repair. Proceedings of the National Academy of Science USA. 109(25):10012-10017.
  56. Hillel AT, Unterman S, Nahas Z, Reid B, Coburn J, Axelman J, Chae J, Guo Q, Trow R, Thomas A, Hou Z, Afthinos A, Matheson C, Walker P, David N, Elisseeff J. (2011) Photoactivated composite biomaterial for soft tissue restoration in rodents and in humans. Science Translation Medicine. 3(93):93ra67.
  57. Coburn J, Gibson M, Bandalini PA, Mao HQ, Laird C, Moroni L, Elisseeff JH. (2011) Biomimetics of the extracellular matrix: An integrated three-dimensional fiber-hydrogel composite biomaterial. Smart Materials and Structures. 7(3):213-222.
  58. Messana J, Hwang N, Coburn J, Elisseeff J, Zhang Z. (2008) Size of embryoid body influences chondrogenesis of mouse embryonic stem cells. Journal of Tissue Engineering and Regenerative Medicine. 2(8):499-506.
  59. Agrawal SK, Sanabria-DeLong N, Coburn J, Tew GN, and Bhatia SR. (2006) Novel drug release profiles from micellar solutions of PLA-PEO-PLA triblock copolymer. Journal of Controlled Release, 112:64-71.

Conference Proceedings

  1. Agrawal SK, Sanabria-DeLong N, Jemian PR, Coburn JM, Tew GN, and Bhatia SR. (2005) Micro- to nano-scale structure and drug release behavior of solutions and hydrogels of poly(lactide)-poly(ethylene oxide)-poly(lactide) triblock copolymers. Materials Research Society Symposium Proceedings. 897:75-80.

Book Chapters

  1. Coburn JM, Elisseeff JH. (2011) Engineering cartilage: From materials to small molecules. In Li S, L-Heureux N, Elisseeff JH (Eds.), Stem Cells and Tissue Engineering (pp.181-201). Hackensack, NJ: World Scientific Corp.