Manning Lab Publications (since 2015)

Zamalloa LG, Pruitt MM, Hermance NM, Gali H, Flynn RL, Manning AL. 2023 RB loss sensitizes cells to replication-associated DNA damage following PARP inhibition. Mar. bioRxiv. PMID 36993348

Mercadante DL, Aaron WA, Olson SD#, Manning AL#. Cortical Dynein Drives Centrosome Clustering in Cells with Centrosome Amplification. Molecular Biology of the Cell. May 15. PMID 37017483 # indicates co-corresponding authors

Crowley EA, Hermance NM, Herlihy CP , Manning AL. 2022. Suppression of chromosome instability limits acquired drug resistance. Molecular Cancer Therapeutics. Oct 7. PMID: 36116892

Rajasekaran S, Khan E, Ching SR, Khan M, Siddiqui JK, Gradia DF, Lin C, Bouley SJ, Mercadante DL, Manning AL, Gerber AP, Walker JA, Miles WO. 2022. PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing. Nucleic Acid Research. June 23. PMID: 35736218

Herlihy CP, Hahn S, Hermance NM, Crowley EA, Manning AL. 2021. Suv420 enrichment at the centromere limits Aurora B localization and function. J Cell Sci 134(15). PMID 34342353

Mercadante DL, Manning AL, Olson SD. 2021. Modeling reveals cortical dynein-dependent oscillations in bipolar spindle length. Biophys J 120(15): 3192-3210. PMID: 34197801.

Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance NM, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. 2021. Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature 590(7846):492-497. PMID 33505027

NM Hermance, EA Crowley, CP Herlihy, AL Manning. 2020. Enhanced cohesion promotes chromosome stability and limits acquired drug resistance in non small cell lung cancer. bioRxiv.

Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT. 2020. Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemica: a single arm, phase 2 trial. Lancet Haematol. 7(2)e122-e133. PMID 31837959

Mercadante DL, Crowley EA, Manning AL. 2019. Live Cell Imaging to Assess the Dynamics of Metapahse Timing and Cell Fate Following Mitotic Spindle Perturbations. J Vis Exp. (151). PMID 3158921

Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. 2019. Identifiation of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun. 10(1): 1547. PMID 30948712

Navarro-Serer B, Childers EP, Hermance NM, Mercadante D, Manning AL. 2019. Aurora A inhibition limits centrosome clustering and promotes mitotic catastrope in cells with supernumerary centrosomes. Oncotarget. 10 (17): 1649-1659. PMID 30899434

Fathi AT, Wander SA, Blonquist TM, Brunner AM, Amrein PC, Supko J, Hermance NM, Manning AL, Sadrzadeh H, Ballen KK, Attar EC, Graubert TA, Hobbs G, Joseph C, Perry AM, Burke M, Silver R, Foster J, Bergeron M, Ramos AY, Som TT, Fishman KM, McGregor KL, Connolly C, Neuberg DS, Chen YB. 2017. Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia. Haematologica. 102 (4): 719-727. PMID 28034990

Nicolay BN, Danielian PS, Kottakis F, Lapek JD Jr, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ. 2015. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes Dev. Sep 1;29(17):1875-89. PMID 26314710