Manning Lab

Dr. Amity Manning

Nicole Hermance: Technician Extraordinaire

Genome Instability and drug resistance in non small cell lung cancer

Nicole received a BA degree in Biology from Saint Anselm College before working at UMASS Medical School exploring the pathways that control inflammation and to understand the genetic basis of T cell acute lymphoblastic leukemia (T-ALL) using a mouse model. Nicole joined the Manning lab in April 2015. Her project is focused on uncovering the cause and consequence of genome instability in cancer.  She is using molecular and imaging techniques to manipulate genome instability in cell culture and in mouse xenograft models, and testing the impact of such changes on tumor cell growth, viability, and drug response.

Graduate Students

Robert Belmonte

Robert is an MS candidate in Biotechnology who joined the lab in 2021. Rob is working to define the role of phospho-regulation in Suv420 function.

Sudheshna Bodapati

Sudheshna is an MS candidate in the Bioinformatics and Cell Biology Program. She joined the lab in 2021. Her project seeks to understand how cancer-relevant mutations in the Histone Methyltransferase Suv420 impacts substrate recognition and methyltransferase activity.

Elizabeth Crowley

Liz is a PhD candidate in the Biology and Biotechnology program. She joined the lab in January 2018. Her project is investigating mitotic mechanisms of genomic instability.

Weikang Fu

Weikang is a PhD student in the Biology and Biotechnology program. He joined the lab in January 2022.

Sabine Hahn

Sabine is a PhD student in the Biology & Biotechnology program. She received a BA in Biochemistry & Molecular Biology and a BA in Religion from  Cornell College in Mount Vernon, Iowa.  She joined the Manning Lab in 2018 and is interested in understanding how pRB loss influences heterochromatin regulation and organization.

Dayna Mercadante

Dayna is a PhD student in the Bioinformatics and Computational Biology Program and is co-mentored by Sarah Olson in the math Department. She joined the Manning/Olson labs in September 2017 and her thesis project uses mathematical modeling and cell biological approaches to investigate the dynamic regulation of spindle structure

Luis Gregory Gutierrez Zamalloa

Greg is a PhD student in the Biology and Biotechnology graduate program at WPI. He joined the Manning lab in January 2019. His project is focused on identifying and exploiting epigenetic weaknesses in cells that lack the pRB tumor suppressor

Undergraduate Students

Kylie Belanger

Biology and Biotechnology Major, Graduating Class of 2022

Cristian Nunez

 Biology and Biotechnology Major, Graduating Class of 2022

Mikhail Rashkovskii

Biochemistry Major, Graduating Class of 2023

Emma Smith

Biomedical Engineering, Graduating Class of 2023