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Metadynamics simulations reveal mechanisms of Na and Ca transport in two open states of the channelrhodopsin chimera, C1C2. Lindsey A. Prignano, Mark J. Stevens, Juan M. Vanegas, Susan B. Rempe and Robert E. Demppski. Plos One (2024) https://doi.org/10.1371/journal.pone.0309553.
Unlocking the Brain’s Zinc Code: Implications for Cognitive Function and Disease. Soheila Sabouri, Marzieh Rostamirad and Robert E. Dempski. Frontiers in Biophysics (2024) https://doi.org/10.3389/frbis.2024.1406868.
FlowAR: A mixed reality program to introduce continuous flow concepts. Max Chen, Yichen Li, Hilson Shrestha, Noelle Rakotondravony, Andrew Teixeira, Lane Harrison and Robert E. Dempski. Journal of Chemical Education (2024) 101 1865-1874.
Single-molecule quantification of the oligomeric state of ZIP transporters in mammalian cells with fluorescence correlation spectroscopy. Yuting Liu, Elizabeth M. Bafaro and Robert E. Dempski. Methods in Enzymology (2023) 687 103-137.
WheelUp! Developing an interactive electric power wheelchair virtual training environment. Max Chen, Yihong Xu, Alexander Sirois, Yichen Li, Robert Dempski, Gillian Smith, Yuko Oda, Yunus Telliel, Erika Lewis and Kelilah L. Wolkowicz. IEEE Conference on Games (2023).
Channelrhodopsin C1C2: Photocycle kinetics and interactions near the central gate. van Gordon, M., Prignano, L., Dempski, R.E., Rick, S. and Rempe, S. Biophysical Journal. (2021) 120 (9) 1835-1845
A fast, simple student generated Augmented Reality approach for protein visualization in the classroom and home study. Arguello, J. and Dempski, R.E. J. Chemical Education. (2020) 97 (8) 2327-2331.
Channelrhodopsin-2 function is modulated by residual hydrophobic mismatch with the surrounding lipid environment. Richards, R., Mondal, S., Weinstein, H. and Dempski, R.E. Applied Biosciences and Bioengineering. (2019) 9 (13) 2674.
Quantifying the Oligomeric State of hZIP4 on the Surface of Cells. Ahern, M.E., Bafaro, E.M., Cowan, A. and Dempski, R.E. Biochemistry. (2019) 58 (13) 1705-1708.
Concomitant disorder and high affinity zinc binding in the hZIP4 intracellular loop. Bafaro, E.M., Maciejewski, M., Hoch, J. and Dempski, R.E. Protein Science. (2019) 28 (5) 868-880.
An optimized and automated approach to quantifying channelrhodopsin photocurrent kinetics. Prignano, L., Faal, S.G., Hera, A. and Dempski, R.E. Analytical Biochemistry. (2019) 566, 160-167.
Increasing enthusiasm and enhancing learning for biochemistry-laboratory safety with an Augmented-Reality Program. Zhu, B., Feng, M., Kesselman, J. Harrison, L., and Dempski, R.E. Journal of Chemical Education. (2018) 95, 1747-1754.
The emerging role of zinc transporters in cellular homeostasis and cancer. Bafaro, E.M., Liu, Y. and Dempski, R.E. Signal Transduction and Targeted Therapy. (2017) 2, pii 17029. doi: 10.1038/sigtrans.2017.29
Adjacent channelrhodopsin-2 residues within transmembranes 2 and 7 regulate cation selectivity and distribution of the two open states. Richards R. and Dempski R.E. Journal of Biological Chemistry (2017) 292, 7314-7326.
Zinc at a cellular crossroads. Liang, X., Dempski, R.E. and Burdette, S.C. Current Opinion in Chemical Biology (2016) 21, 120-125.
Voltage clamp fluorometry of P-type ATPases. Dempski, R.E. Methods in Molecular Biology. (2015) 1377, 281-291.
From phototaxis to biomedical applications: Investigating the Molecular Mechanism of Channelrhodopsins. Richards, R. and Dempski, R.E. Springer Series in Biophysics. (2015) 18, 361-381.
A Zinc(II) Photocage Based on a Decarboxylation Metal Ion Release Mechanism for Investigating Homeostasis and Biological Signaling. Basa, P., Antala, S., Dempski, R.E. and Burdette, S.C. Angewandte Chemie. 54 (44) 13027-13031 (2015).
Cysteine substitution and labeling provides insight into channelrhodopsin-2 ion conductance. Richards, R. and Dempski, R.E. Biochemistry. 54 (37) 5665-5668 (2015).
The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain. Bafaro, E.M., Antala, S., Nguyen, T.V., Dzul, S., Doyon, B., Stemmler, T.L., and Dempski, R.E. Metallomics. 7 (9) 1319-1330 (2015).
Computational modeling and functional studies provide a structural scaffold for the zinc transporter hZIP4. Antala, S., Ovchinnikov, S., Kamisetty, H., Baker, D., and Dempski, R.E. J. Biological Chemistry. 290, 17796-17805 (2015).
Transmembrane domain three contributes to the ion conductance of channelrhodopsin-2. Gaiko, O. and Dempski, R.E. Biophysical Journal, 104, 1230-1237 (2013).
Re-introduction of transmembrane serine residues reduce the minimum pore diameter of channelrhodopsin-2. Richards, R. and Dempski, R.E. Plos One, 7, e50018 (2012).
The cation selectivity of the ZIP transporters. Current Topics in Membranes. Dempski, R.E. 69, 221-245 (2012).
The human ZIP4 transporter has two distinct binding affinities and mediates transport of multiple transition metals. Antala, S. and Dempski, R.E. Biochemistry, 51, 963-973 (2012).
Examining the conformational dynamics of membrane proteins in situ with site-directed fluorescence labeling. Richards, R. and Dempski, R.E. Journal of Visualized Experiments, 15, (2011).
Ultra light-sensitive and fast neuronal activation with the Ca++ permeable Channelrhodopsin, CatCh. Kleinlogel, S., Feldbauer, K., Dempski, R.E., Fotis, H., Wood, P.G., Bamann, C. and Bamberg, E. Nature Neuroscience, 14, 513-5518 (2011).
Ligand-dependent effects on the conformational equilibrium of the Na,K-ATPase as monitored by voltage clamp fluorometry. Geys, S., Bamberg, E., and Dempski, R.E. Biophysical Journal, 96, 4561-4570 (2009).